| 共同演者 |
W. T. Kim（Department of Internal Medicine,The Catholic University of Korea, College of Medicine, Seoul, Korea）, B. S. Ko（Department of Internal Medicine,The Catholic University of Korea, College of Medicine, Seoul, Korea）, S. S. Chang（Department of Internal Medicine,The Catholic University of Korea, College of Medicine, Seoul, Korea）, E. H. Kim（Department of Internal Medicine,The Catholic University of Korea, College of Medicine, Seoul, Korea）, W. S. Park（Department of Internal Medicine,The Catholic University of Korea, College of Medicine, Seoul, Korea）, Y. S. Kim（Department of Internal Medicine,The Catholic University of Korea, College of Medicine, Seoul, Korea）, S. B. Kang（Department of Internal Medicine,The Catholic University of Korea, College of Medicine, Seoul, Korea）, S. W. Nam（Department of Internal Medicine,The Catholic University of Korea, College of Medicine, Seoul, Korea）, D. S. Lee（Department of Internal Medicine,The Catholic University of Korea, College of Medicine, Seoul, Korea）, H. Y. Jeong（Departments of Internal Medicine,of Chung Nam National University Hospital）, J. M. Kim（Pathology of Chung Nam National University Hospital） |
| 抄録 |
Background: Signal transducers and activators of transcription (STATs) activation plays a role in the modulation of activity for downstream mediators such as Bcl-xL or MMP2. We investigate the immunohistochemical expressions of STAT3, Bcl-xL and MMP-2 proteins according to the histopathological parameters such as lymph node metastasis, tumor differentiation, the TNM stage and the tumor size in colon adenocarcinoma.Method: Immunohistochemical staining with monoclonal STAT3, Bcl-xL and MMP-2 antibodies was performed on the paraffin embedded specimens from 20 colon adenomas and 39 adenocarcinomas. Results: The expressions of STAT3, Bcl-xL and MMP-2 were increased in the adenocarcinomas as compared to the adenomas (p<0.001). The STAT3 expression was stronger in the tumor with distant metastasis than that in the tumor without it (p=0.012). The larger tumor size was related with a stronger STAT3 expression (p<0.035). Conclusion: STAT3, Bcl-xL and MMP-2 may play an important role in the tumorigenesis of colorectal carcinoma. STAT3 may be related to a poor prognosis because of its correlation with distant metastasis and a larger tumor size. |
