| セッション情報 |
International Forum 2(Liver) 2.Pathology
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| タイトル |
IF2-2-II (Keynote lecture) Early HCC: Diagnosis and molecular markers
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| 演者 |
Michiie Sakamoto（Department of PathologyKeio University School of MedicineTokyoJapan） |
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| 抄録 |
Hepatocellular carcinoma （HCC） is one of the most common malignant tumors． HCC occurs mainly inchronically diseased livers such as hepatitis B and C infection． These high risk patients are closely fol－lowed upand increasing numbers of small equivocal lesions are detected by imaging diagnosis． They arenow widely recognized as precursor or early－stage of HCC and are classified as Dysplastic Nodule orearly HCCThese lesions lack typical imaging and histology of ordinary HCC and do not show elevated se－rum markers such as AFP and PIVKA－II． Comprehensive analyses of gene expression of these lesionswould help development of molecular markers for objective histological diagnosis of early HCC and possi－bly new serum markers for early detection of HCC． We so far identified that Hsp 70 and CAP2 are up－regulated in a stepwise manner in multistage hepatocarcinogenesis． lmmunohistochemical applications ofthese two molecules indicated that they could be sensitive markers for the differential diagnosis of earlyHCC from precancerous lesions or non－cancerous liverwhich is difficult even for experienced patholo－gists because of very well differentiated histology with little atypia in early且CC． It has also been reportedthat Glypican 3 and Glutamine Synthetase could serve as molecular markers for early HCC． ln additionanalyses of stemness signatures have been widely introduced to better understanddiagnoseand treatcancers． We have shown that Bmi－1 gene was expressed in the HCC regionand in particular it washighly expressed in early and well－differentiated HCC． A possible down－stream target of Bmi－1 is nowunder investigationwhich may contribute to early hepatocarcinogenesis and may function as a novelmarker for early HCC． These efforts are expected to establish practically useful molecular markers forroutine pathological diagnosis including biopsy diagnosis and also serum markers for early detection ofHCC． |
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