| セッション情報 |
一般演題(口演)
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| タイトル |
043 Overexpression of osteopontin is associated with vascular invasion and predicts poor survival in patients undergoing hepatectomy for hepatocellular carcinoma
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| 演者 |
Pavel Korita（新潟大学消化器・一般外科.） |
| 共同演者 |
若井俊文（新潟大学消化器・一般外科.）, 白井良夫（新潟大学消化器・一般外科.）, 坂田純（新潟大学消化器・一般外科.）, 井上真（新潟大学消化器・一般外科.）, 味岡洋一（新潟大学大学院分子・診断病理）, 畠山勝義（新潟大学消化器・一般外科.） |
| 抄録 |
This retrospective study evaluated the immunohistochemical expres-sion of cell adhesion molecules （CAMs） ： E-cadherinP-cateninandosteopontin in 125 surgically resected specimens of hepatocellular car-cinoma （HCC）． This study aimed to identify factors associated withvascular invasion and to elucidate the prognostic value of CAMs． Theimmunoreactivity of E-cadherinb-cateninand osteopontin was sig・nificantly associated with Edmondson-Steiner gradebut not with tu-mor size． The incidence of vascular invasion was 35％． The logistic re-gression analysis revealed that tumor size ＞3 cmEdmondson-Steinergrade III-IVand overexpression of osteopontin were independentlyassociated with vascular invasion． The Cox proponional hazard regression analysis revealed that Edmondson-Steiner grade lll-IV （relativerisk ［RR］3．028：P〈O．OO1）the presence of vascular血vasion （RR1．964 ； P＝O．O11）overexpression of osteopontin （RR1．755 ； P＝ 0.034）serum alpha-fetoprotein level ＞20ng／mL （RR1．8sc ； P＝O．037）andChild-Pugh classification B-C （RR1．880 ； P＝O．caO） were found to beindependentiy signhicant factors associated with survival after he-patectomy． These results suggest that among the tested CAMs ex-pressionoverexpression of osteopontin independently correlates withvascular invasionand thus predicts a poor prognosis for patients withHCCwhereas E-cadherin and b-eatenin expression do not． |
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