| セッション情報 |
Session 1
Human Gut Microbiome in Health and Disease
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| タイトル |
IF1-3 Molecular Analysis of the Diversity of the Gut Microbiota of Health and Disease(IBD)in Japanese Population
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| 演者 |
Akira Andoh（Division of Mucosal ImmunologyGraduate SchoolShiga University of Medical ScienceJapan） |
| 共同演者 |
Hirotsugu Imaeda（Division of Mucosal ImmunologyGraduate SchoolShiga University of Medical ScienceJapan）, Yoshihide Fujiyama（Division of Mucosal ImmunologyGraduate SchoolShiga University of Medical ScienceJapan） |
| 抄録 |
The continuous contact between・commensal bacterial and the single epithelial cell layer of the mucosal tis-sue is a characteristic feature of the gastrointestinal system． ln particularinteraction between -commen＄albacteria and mucosal immune system plays an important role in keeping health and disease development．hiammatory bowel diseases are chronic intestinal di＄orders of unknown etiology in which in geneticallysusceptible individualsthe mucosal immune system shows an aberrant response towards luminal anti－gens such as dietary factors and／or commensal bacte． riaThe relation between a dysregulated bacterialecosystem and mucosal inflammation in IBD has been demo／nstrated in a variety of clinical and basic lit－eratures． The gastrointestinal tract has developed elaborate mechanisms to coexist with its autologous mi－crobiotabut rapidly respond to invading pathogens and then return to homeostasis with its commensalbacteria after the pathogenic infection is cleared． lf these tightly regu／lated ’homeostatic mechanisms aredisturbedchronic intestinal inflammation may be induced． Previous studies demonstrated that some com－me／nsal bacteria are detrimentaland others have no effect or are protective． ln additioneach host has agenetically determined response to detrimental and protective bacterial species． Environmental and ge－netic factors modulate the relative balance of beneficial and detrimental bacterial speciessuggesting thattherapeutic manipulation of this balance can influence health and disease． This paper focuses on new in－sights into the role of commensal bacteria in gut health and diseaseand presents recent advances intherapeutic approaches to modulate imbalance of intestinal microbiota in IBD patients． |
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