| セッション情報 |
Host-microbial Interaction and Immunology in IBD b. Clinical Aspects
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| タイトル |
IF3b-3 Immunological Aspect in the Treatment of IBD
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| 演者 |
Takayuki Matsumoto（Department of Lower GastroenterologyHyogo College of MedicineJapan） |
| 共同演者 |
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| 抄録 |
The etiology of IBD comprises multiple factorssuch as geneticsintestinal microflora and immunologi－cal abnormalities of the host． Although true mechanisms of the gut inflammation remain unclearrecentadvances in the treatment with the biologics bring us maj or improvement in the outcome of the medicaltherapy． Howeverit is still hard to predict the long－term outcome of the treatment with new therapies．We have investigated the local immune responses in the IBD patients． ln Crohn’s disease （CD）pre－dominant Thl responses were observed in the granulomatous lesion in the mucosa and mesenteric 1ymphnodes with oligoclonal activation of the CD4 lymphocytesContrarypolyclonal activation of CD4 lympho－cytes and unregulated infiammatory cytokines were observed in the mucosa of ulcerative colitis （UC）．In patients with CDwe have evaluated the SNPs in plasminogen activator inhibitor type 1 （PAI－1）which may play key roles in the control of fibrotic changes in the infiammatory cite． ln patients with dis－abling phenotypes of CDprevalence of 4G／4G genotype was greater than that of 5G genotype．In patients with ulcerative colitis taking apheresis therapyregulatory T cells are often up－regulatedjust after the apheresisand could be one of the markers predicting therapeutic efficacy． On the contraryin patients who needed colectomyregulatory T cells were lower even after the surgerywhich suggestsunderlining immune impairments for such intractable patient group． |
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