| セッション情報 |
Enteric Viral Hepatitis i)Epidemiology of Hepatitis A and E
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| タイトル |
IF4a-2 Viral Hepatitis A and E in Japan
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| 演者 |
Yoko Tamada（Clinical Research CenterNational Hospital Organization(NHO)Nagasaki Medical CenterJapan） |
| 共同演者 |
Hiroshi Yatsuhashi（Clinical Research CenterNational Hospital Organization(NHO)Nagasaki Medical CenterJapan） |
| 抄録 |
Objective ：To examine recent trends of hepatitis A （AHA） and hepatitis E （AHE） in Japan．Methods ：During 1980 through 2010sentinel surve皿ance was conducted in 31 national hospitals in a prospective co－hort study． All cases of viral acute hepatitis （VAH） which wereadmitted to one of our hospitals have bee－nsequentialJy enrolled． Lo／ngitudinallythey were categorized into three periods ； the l st （1980－1989）2 nd（1990－1999）and 3rd （2000－2009）．Resut’ts ：A total of 4524 cases of VAH were enrolled． Hepatitis ABCE and non－ABCI was found in 1612（35．6 9／o ）1294 （28．6 0／o ）385 （8．5 0／o ）56 （12 0／o ）and 11 77 （26 ．0 0／o ）respectively．AHA accounted for 37．50／o （687／1830） in the lst period48．50／o （718／1481） in the 2ndand 16．80／o （186／1107） in the 3rd （lst vs． 3rdp〈O．OOOI ； 2nd vs． 3rdp〈O．OOOI）． The male ratio was 54 0／o． The mean agewas 34．6 in the lst period38．8 in the 2ndand 41．1 in the 3rd （lst vs． 2ndp〈O．05 ； 2nd vs． 3rdp〈O．05）． Se－vere acute hepat’itis （SAH） and fulminant hepatitis （FH） developed in 54 （3．30／o） and 8 （O．50／o） patientsrespectively． They （SAH ＋FH） accounted for 1．90／o in the lst period320／o in the 2ndand 1610／o in the 3rd（lst vs． 3rdp〈O．OOOI ； 2nd vs． 3rdp〈O．OOOI） ．AHE accounted fbr O．70／o （13／1830） in the lst periodO．30／o （4／1481） in the 2ndand 3．30／o （36／1107） inthe 3rd （lst vs． 3rdp〈O．OOOI ； 2nd vs． 3rdp〈O．OOOI）． The male ratio was 92．50／o． There was a significantdifference in the mean age between imported and domestic cases （37．3 vs． 526p〈O．Ol）． SAH and FH de－veloped in 1 （1．9 0／o） and O （O O／o） patientrespectively．Conclusion ：In JapanAHA was a major disease among VAH before 2000though it has recently been decreasing．Howeverthe number of severe cases is increasing． Care should be taken in the management of those pa－tients． A且E has increased in males aged middle and older in 200αs than befbre． |
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