| セッション情報 |
Hepatitis B i)Hepatitis B and HCC
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| タイトル |
IF4b-2 Mechanisms of Liver Carcinogenesis ： Focus on HBV Related HCC
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| 演者 |
Pei-Jer Chen（Hepatitis Research CenterNational Taiwan University and HospitalTaiwan） |
| 共同演者 |
Shiow Hwei Yeh（Hepatitis Research CenterNational Taiwan University and HospitalTaiwan）, Ding-Shinn Chen（Hepatitis Research CenterNational Taiwan University and HospitalTaiwan） |
| 抄録 |
Chronic HBV infection has been recognized as one of iMportant cause for liver cancerespecially in theAsia． lt is generally accepted that the carcingogenesis develops via long－term chronic infections and sub－sequent accumulation of genetic mutationswhich finally transform the infected hepatocytes． The presen－tation will discuss the importance of viral factors at first． Epidemiological studies supported a high viralloadcertain viral genetic variants carrying higher risks for HCC．Regarding the host factors influencing liver carcinogenesisthese include the old－agesfamily history andgenderThe male gender is more susceptible to HBV－related H：CC than females． Our studies in ce田ineand in mouse model discovered an promoting role of androgen pathways and in contrastan suppressingrole of estrogen pathway in HBV－related HCCs． This may partially explained the male susceptibdity toHBV－related HCC． ln search for heredity in HBV－related HCCswe previously showed an increased riskamong H BV carriers with familial history of HCC． Now we initiated a genome－wide association study tosearch for possible susceptibility genetic loci． The stage 1 GWAS （Genome－Wide－Association Study） wascompleted and c andidate SNPS are under stage II scrutinizing． The results may shed lights on the mecha－nisms of HBV－related HCCs． There are recently several signaling pathwaysincluding RasWntAkt mole－culesto be involved in maintaining HCC transformation phenotypes． Current molecular therapies target－ing to these pathways may bring new hopes for HCC treatment |
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