| セッション情報 |
Hepatitis C i)Hepatitis C and HCC(II)
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| タイトル |
IF4c-7 Comprehensive Analysis for Viral Genetic Elements and IL28B Polymorphisms in Response to Peginterferon plus Ribavirin Therapy in HCV-1b Infection
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| 演者 |
Nobuyuki Enomoto（First Department of Internal MedicineUniversity of YamanashiJapan） |
| 共同演者 |
Shinya Maekawa（First Department of Internal MedicineUniversity of YamanashiJapan） |
| 抄録 |
To comprehensively characterize the contribution of virological factors as well as interleukin 28B （IL28B）single nucleotide polymorphisms （SNPs） in determining treatment responses in pegylated－interferon plusribavirin （PEG－IFN／RBV） therapy for chronic hepatitis C virus （HCV）一lb infectionwe undertook a ret－rospective cohort analysis for the pretreatment dominant complete HCV open reading frame （ORF） aminoacid sequence study in consecutive 103 HCV－lb Japanese patients． The dominant HCV sequences classi－fied by the response were subj ected to systematic sliding window comparison analysis to characterize re－sponse－specific viral sequences along with IL28B SNPs analyses （rs8099917）． ln each comparison of thepatients between with and without rapid viral response （RVR）non－early viral response （nEVR）sus－tained virological response （SVR） or relapsefollowing regions were extracted as most significantly associ－ated with the different responses respectively ： NSsA aa．2224－2248 （p＝ 1．2E－07）core aa．70 （p ＝4E－04）NS5A aa．2340－2382（p＝7．OE－08）and NS5A aa．2360－2377（p＝1ユE－05）．Those NS5A regions nearly over－lapped with the interferon sensitivity determming region （ISDRNSsA aa．2209－2248） and the interferonribavirin response determining region （IRRDRNSsA aa．2339－2379）． ln a multivariate analysisthe IL28BSNP （OR 16．8p＝O．009） and NSsA aa2340－2382 （OR 13．8p＝O．OOO3） were extracted as the two most sig－nificant independent variables contributing to the final outcome． Conciusion ； ln PEG－IFN／RBV therapypolymorphisms in IL28BNSsA aa．2224－2248coreand most importantlyNS s A aa．2340－2382 have astrong influence on the treatment response in association with the viral kineticsresulting in significantlydifferent outcomes in chronic HCV－lb infection． |
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