| セッション情報 |
Best Poster Award(Lower GI)
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| タイトル |
IF-BP2-2 Colitogenic Effector Memory CD4+ T Cells Develop Th17 Mediated Interstitial Pneumonia Independent to Intestinal Bacterial Antigens
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| 共同演者 |
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| 抄録 |
Background ： Although inflammatory bowel diseases （IBD） often include various extraintestinal manifes－tationslittle is known about their pathogenesis． Recentlywe have reported thatcolitogenic memoryCD4’ T cells were retained outside the intestine independent to intestinal bacterial antigens．’Aim and Methods ： To clarify the role of colitogenic memory CD 4’ T cells for the pathogenesis of ex－traintestinal manifestations of IBDwe have investigated extraintestinal lesion pathologically throughoutthe body of colitis mice．Results：Colitic SCID mice previously transferred with CD4＋CD45RBhigh T ce皿s developed hyperplasia ofinducible bronchus associated lymphoid tissues （iBALT）／ and interstitial pneumoniawhich was sup－pressed completely by transferring with C．D4＋CD25＋regulatory T cells． On the other handora1 admini－stration of antibiotics（ABX）or Ger血free（GF）condition coUld not prevent these lung manifestationswhile they completely prevented to develop colitis． A large number of CD4’CD44’CD62L’IL－7Rcthigh’ effec－tor memory T cells （TEM） infiltrate d in the iBALT and interstitial tissue of lung from colitic SCID mice．These lung CD4’ TEM produced large amount of IL－17 with the stimulation of anti－CD3／CD28 antibody orcecal bacterial lysate． Finallyisolated Lung CD 4’ TEM cells from ABX treated SCID mice or GF SCIDmice previously transferred with CD4“CD45RBhigh T cells indu． ced both colitis and lung manifestationswhen they were transferred to other SCID imice i’n SPF condi’tion．Conclusion ： Here we have proved thatcolitogenic CD4“ TEM develiop ’Th17 mediated lung manifestationsindependent to intestinal bacterial antigenswhich may be one of the pathogenesis of extraintestinal mani－festation of IBD |
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