| 抄録 |
Background ： H.pylori eradication therapy with an o． fficially approved first－line regimen containing a pro－ton pump inhibitor （PPI）clarithromycin （CLR） and amoxiciMn （AMX） fails in a considerable numberof cases because of the increase in the frequency of CLR－resistant fir． pyloriThe aim of the present studywas to compare the efficacy and tolerability of the 7－day first－line H． pylori’ eradication regimen composedof PPL CLR and AMXwith that of PPIMNZ and AMX．Methods ： Data for patientswho were performed first－line H． pylori eradication at the Tokyo medical cen－ter between 2008 an d 2011were reviewed． All patients had H． pylori gastritis without peptic ulcer dis－ease． The 7－day triple regimen composed of PPICLR and AMX was usedin 50 patientswhile that of PPIMNZ and AMX was used in 44 patients． Eradication was confirmed by the results of the i3C－urea breathtest at 12 weeks after completion of the therapy．Resu／lts ： lntention－to－treat（ITT） and per－protocol （PP） eradication rates were 72．00／o and 78．3 for the regimen of PPICLR and AMXwhile 93．2％ and 1000／o for that of PPIMNZ and AMX． No significant differ－ence in the frequencies of adverse events were reported （PPI ＋ CLR ＋ AMX ； 14．00／oPPI ＋ MNZ ＋ AMX ；11．4）． The regimen composed of PPIMNZ and AMX was significantly more effective than that of PPICLR and AMX （p〈O．05 for ITTp〈O．Ol for PP）．Conclusion ： First－line H． pylori eradication therapy compose d of PPIMNZ and AMX was sigriificantlymore effective than that of PPICLR and AMX without difference in tolerability． |
