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BackgroundIt has been postulated that abnormal host／microbial interaction may be involved in the pathogenesis ofIBD． Calprotectin and chitinase 3－like 1 （CHI3L l） might possess a certain role in this regard． Calprotectinis a calcium－binding protein present in the neutrophil cytosol with antimicrobial properties． CHI3Ll is se－creted from epithelial cells under inflammatory conditionssuggested to enhance the adhesion and i’nva－sion Qf potentially pathogenic bacteria such as A dheren t－ln vasive Escherichia coli We evaluate d the cor－relatien of fecal calprotectin and CHI3Ll levels with disease activity．MethodsFecal calprotectin（UC：n＝101CD：n＝94）and CHI3L1（UC＝n＝94CD：n＝87）1evels were deter血inedin pediatric IBD patients and healthy controls （H／C ： n ＝ 56） by ELISAand compared with disease activityusing clinical activity index for pediatric IBD （PUCAIPCDAI） and endoscopic scoring system （Matt－s’№窒≠рC simple endoscopic score for Crohn’s disease） ．ResultsFecal calprotectin （pg／g） was positively correlated with clinical activity （UC ： r ＝ O635CD ： r ＝ O．640p〈O．Ol） and endoscopic activity （UC：r ＝O．838CD：r＝＝O．740p〈O．Ol）．Fecal CHI3Ll （ng／g） was signifi－cantly higher in clinically active phase than remission and H／C （UC ： 915．0±1510．2 vs 123．5±259．5CD ：1274．1±1809．1vs 323．2士670．9H／C：4．8±6．6p＜0．01）and strongly correlated with endoscopic activity（UC ： r＝ O．73p〈 O．OlCD ： r＝ O．61p〈 O．Ol）．ConclusionCalprotectin and CHI3Llwhich might be included in host／microbial interactionwere markedly elevatedin feces of active IBD patientsAlthough the biological roles of elevated these proteins should be proven infuturefecal・calprotectin and CHI3Ll might be novel biomarkers of disease activity because they stronglyreflect mucosal inflammation． |
