| セッション情報 |
Poster Presentation(GI)
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| タイトル |
IF-P1-4 CMV Antigenaemia as a Marker of Targeting Cytomegalovirus Infection in Patients with Refractory Moderate to Severe Ulcerative Colitis
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| 演者 |
Koji Kamikozuru（Department of Lower GastroenterologyHyogo College of MedicineJapan） |
| 共同演者 |
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| 抄録 |
Introduction ： lt has been reported that overlapped infection with Cytomegalovirus （CMV） could triggerthe exacerbation of ulcerative colitis （UC） and lead to the refractoriness to conventional therapy． Howeveran accurate diagnosis of CMV infection to be treated with antiviral therapy remains unclear．Aims ＆ Methods ： 186 patients with active UC admitted to our department between April 2007 and March2010were enrolled in the study． CMV infection was detected when at least one of the following tests waspositive ； CMV antigenaemia （C7－HRP）PCR on peripheral bloodPCR on biopsy or histological examina－tion． The prevalencediagnosisand the effectiveness of antiviral therapy in these patients were investi－gated． We also assessed the factors impacted the outcomes of the therapy．Results ： 84 of 186 patients （4520／o） were positive for CMV． Among 84 CMVpositive patients59 weretreated with ganciclovirand 16 responded to this medication and achieved clinical remission without addi－tional immunosuppressive therapies （clinical responders）ln the multivariate analysisthe positive ratesand the positive cell numbers for CMV－antigenaemia were higher in the clinical responders than the restof the patients （4．17／50000 vs． 2．22／50000P〈O．05）． ln additionthe amount of prednisolone within the pre－vious 4 weeks were signt丘。．antly high in the clinical responder． Du血g the 27．9 months fbllow－up periodcolectomy rate of clinical responders were ilower than the rest patients．Conclusion ： CMV over－infection may affect the prognosis of UC． Our data showed high positive cell num－bers for CMV antigenaemia could be used as a marker for antiviral therapy． |
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