| セッション情報 | Poster Presentation(GI) |
|---|---|
| タイトル | IF-P1-7 The Effect of Dai-kenchu-to in Maintenance of Microbiomal Diversity on Intestinal Inflammation |
| 演者 | Kozo Yoshikawa（The University of TokushimaJapan） |
| 共同演者 | M Shimada（The University of TokushimaJapan）, N Kurita（The University of TokushimaJapan）, T Iwata（The University of TokushimaJapan）, H Sato（The University of TokushimaJapan）, M Nishioka（The University of TokushimaJapan）, S Morimoto（The University of TokushimaJapan）, T Miyatani（The University of TokushimaJapan）, H Kashihara（The University of TokushimaJapan）, C Takasu（The University of TokushimaJapan） |
| 抄録 | ［Purpose］Diversity of microbiome is lost in inflammatory bowel disease （Gastroenterology 2009）． We have alreadyreported that the Dai－kenchu－to （DKT） prevented the bacterial translocation through suppression of cy－tokine and apoptosis （Dig Dis Sci 2008）． The hypothesis is microbiome related anti－inflammatory effects ofDKT． The aim of this study was to evaluate the effect of DKT on maintenance of microbiomal diversity inintestinal inflammation．［MethodコThe wister rat was received the fast stress for 5 days （F－group）． The microbiome of stool was examinedat pre一 and post一 fast stress． ln DKT grouprat was administered the DKT （300mg／kg／day） during the faststress （D－group）and the effect of DKT was examined． Microbiome was examined by terminal restrictionfragment length polymorphism analysis and diversity was analyzed by operational taxonomical unit（OTU） ．［Result］］n F－groupErysipelotrichaceae increased to 860／o in post fast stressOTU of pre－fast stress was 111 andpost－fast stress was 46 （changing rate ： 58 O／o ） ． The diversity of microbiome was severely decreased． On theother handin D－groupdiversity of microbiome was kept after fast stress（Lac加ospiraceae ： Ruminococ－caceae： Coriobacteriales 540／o220／o5％）OTU of pre－fast stress was 52 and post－fast stress was 55（changing rate ： 50／o ）． DKT maintained the diversity of microbiome in fast stress model．［Conclusion］DKT maintained the diversity of microbiome in fast stress modelOur data suggested the new mechanisrnof anti－inflammatory effect of DKT． |
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