| 抄録 |
Background ： IL28B polymorphisms were shown to be associated with response to peg－interferon basedtreatment hl chronic hepatitis C（C且C）and spontaneous clearance． Howeverlittle is known about howthis factor affects the course of CHC including the development of hepatocellular carcinoma （HCC）．Aims ： To evaluate the influence of IL28B polymorphisms on hepatocarcinogenesis in patients with CHC．Methods ： we genotyped the rs8099917 single－nucleotide polymorphism in 351 C－associated HCC patientswithout history of IFN－based treatmentand correlated the age at onset of HCC in patients with eachgenotype．Results ： Frequencies of TTTGand GG genotypes were 74．30／o （261／351）24．80／o （87／351）and O．90／o （3／351）respecbively． The mean ages at onset of HCC for TTTGand GG genotypes were 69．967．5 and 66．8respectively． ln multivariate analysisIL28B minor allele （TG and GG genotypes） was extracted as an inde－pendent risk factor for early－age onset of HCC （p＝O．02） with higher BMI （p＝O．009） and male ge／nder（p〈O：OOOI）． IL 28 B minor allele was also associated with lower probability of having aspirateaminotransferase－to－platelet ratio index （APRI） ＞1．5 （minor vs． major46．70／o vs． 58．60／o ； p＝O．Ol）lowerAST （69．1 vs 77．7 IU／1p＝O．02）lower ALT （67．8 vs． 80．9 IU／1p＝O．002）higher platelet count （12．8 vs．11．2 × 104／plp ＝ O．002）and higher prothrombin time （79．30／o vs． 75．4 O／op ＝ O．002） after adjustment for gen－derBMIalcoholic consumptionand the age at enrollmentConclusions ： IL28B minor allele was associated with lower inflammatory activity and less progressed fi－brosis of liverhoweverconstituted a risk factor for early－age onset of HCC in patients with CHC． |
