| セッション情報 |
Panel Discussion 8
Medical Science Communication at the GlobalAge Part2:The Future of Gastroenterology in Asia
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| タイトル |
PD8-2-3 Recent Advances in Autoimmune Pancreatitis
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| 演者 |
Kazushige Uchida（Kansai Medical UniversityJapan） |
| 共同演者 |
Kazuichi Okazaki（Kansai Medical UniversityJapan） |
| 抄録 |
International consensus diagnostic criteria for autoirnmune pancreatitis（AIP）de且ne two subtypes：Type l AIPre且ated to IgG4：and Type 2AIPrelated／ to a granulocytic epithelial lesion． The clinicopathologicalfeatures of Type 1 AIP are suggestive of abnormal immunity such as al－lergy or autoimmmity． Moreoverpatients with Type 1 AIP often haveextrapancreatic lesions showing pathologieal features sirnilar to the pan－creatic lesions． Of interest many synonyms have been proposed for theconditions of AIP and extrapanereatic lesionssuch as “multifocal idi－opathic fibrosclerosis “lgG4－related autoirrmiune disease， “lgG4－r＆lated sclerosing disease “systemic lgG 4－related plasmacytic syn－ drome， and “lgG4－related multiorgan 1ymphoprourerative syndrome”．Theref（）rethe Research Progra皿for lntractable Disease proposed“lgG4－related disease” ．Although AP is accepted worldwide as a unique ciinical entityits path｝genetic mechanism remains unclear． We hypothesize that the pathogene－sis of Type 1 AP based on our recent studies． ln the early stagethe in－i廿al response to se匠一aR艇gens （for examples：lact◎fer血carbonic anhy－drase－lland pancreatic secretory trypsin inhibitor） is induced by de－creased naive regulatory T cells and T－he1per （Th） 1 imrnune responsesIn the chronic stagepregression is supported by increased Tregs andTh2． The productio且of IgG4 may be regulated by increased ICOS＋Tregs via皿一10． As Tregs seem to play an important role血progressionas wen as in induction of the diseasefurther studies are necessary toclarifY the pa血ogenesis of AIP and estab丘sh the disease concept、 |
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