| セッション情報 |
Panel Discussion 8
Medical Science Communication at the GlobalAge Part2:The Future of Gastroenterology in Asia
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| タイトル |
PD8-2-6 Insight to Ischaemia-Reperfusion Injury(IRI)in Cadaveric Liver Transplantation(LT)Through Metabolomic Studies―Will it Shift the Paradigm of Liver Transplant Practice?
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| 演者 |
Thamara Perera（Multi Organ Retrieval and Liver Transplant Queen Elizabeth HospitalBirmingham UK） |
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| 抄録 |
With inereased demand for LTscarcityof donor organs remainsan obstacle to aecess to transpimtatien for many．deserving patientS↓iver donorLT（LDLT）papUlar il Asia iS鋤op極o皿that requ辻es geeat cau廿σ凡however玲sults in good qualit了graf捻Depeロ“㎝ce．of．cadave配donor pool means． va！iable graft・qnalifywlth a sign血￠antpropartion being marginal grafts from denation after eardiac death （DCD）／ doncrs Prirriary non－imction （PNF）・ anddelayed graft fUnction（DGF）a泥［najor barriers for the op血［al useαrsuch graft＆We hypo廿ieSized study of me幽lo蜘￡皿v舷瞬曲q麟蘭。㎝ey．面舳a醐h⑳㎎幡瞬蜘1贈sido留A醐醜grafts On DBD：13DCD）wαe studied w㎞出。郎誼biop血s副岡withFo曲蹴舳m．ion cydotrone 1輪蹄（剛CR）mass・s麟。me齢皿e㎡㎝劇贈sco皿㏄t曲m do皿orω．pQst reperfUsion phase were an・a』ysed w曲high pe鰍e旺quid d1銅）matography （HPI￡）Addi百onal basic me塩L⑩腫。 dla皿ges were a且訓ysedto see panerns of glucese metabolismiactate ； pyruvate ratio etcPutative as／signment of metabolites ’idendiedthraugh FTICR－ws was carried out pvith referenee tothe Kyoto Eneyclopedia of・fene and Gen． ome （asGG） data－baseThe early resUltS ofongo血g analysis by PCA scores plot revealed clear separatian between cold ph．ase biop・sles compared to those nken・post reperfusiolt 1iniited biopsles’in the doner phase were clustered along ’with postreperfusion． in im Univarinte analysis・24Q2 reproducibly detectted peaks for positive ion mode af which 14es peaks（61欄討蝉。爵晩rb厳n cdld pl臨鋤d圃re帥甑To掘of伽畑（275％lwe祀蜘i翫祖ぜy雌τb￠癬eeR DBD脇d㏄D魚r cdd pbase whlch面p撃ove“憩g 283pe呂ks（11．78％）post rep曲s臨0贈a聾21 sig雌an廿y雌re皿t卿職s血Ciuding carbohydrate〔6pathwayS：8compOunds）1a㎞o．aCid（4 pa出wヨys；8c㎝・pounds） and lipid （1 pathw・ay ；3 compounds） metaboksm were seen in DBD grafts aher reperfusi’enwhen com－paτed to DCD gr雌s and hld岨ed pyruvateglycorylatefructaseleudロe’lys血e a皿d trypt⑪phan rnetabOlismsAbik’狽凵@to repllcate rhese results in neLC mass spectrometry means bener inslght to mu between DCD and DBD9廊舳．OP暉画瞭r止erapeutic interventiens aimed at騨ft revivaL |
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