セッション情報 The 2nd JSGE International Topic Conference

5)Inflammation and Carcinogenesis in the Biliary Tract and Pancreas

タイトル IT5-1:

New Insights into the Molecular Pathogenesis of Intrahepatic Cholangiocarcinoma

演者 Patel Tushar(Department of Transplantation, Mayo Clinic Florida, USA)
共同演者
抄録 Intrahepatic cholangiocarcinoma(ICC)is an aggressive malignancy which has a very poor prognosis. The mechanisms involved in the pathogenesis of these cancers are not well understood. Recent epidemiological and genome-wide profiling studies have provided some new insights with an improved understanding of risk factors, specific genetic mutations and mechanisms that are associated with this rare tumor. Key pathways of importance in disease pathogenesis such as IL6/STAT, hepatocyte growth factor/MET, epidermal growth factor, vascular endothelial growth factor and KRAS/mitogen-activated protein kinase will be reviewed with an emphasis on the role of inflammation. The implications of these new insights for molecular diagnosis and therapy will be reviewed. We will also outline the broader relevance of distinguishing intrahepatic cholangiocarcinoma from other tumors such as extrahepatic or ductal cholangiocarcinoma and hepatocellular carcinoma, the importance of defining the pathogenesis and other emerging topics of relevance.
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