| 共同演者 |
Sasaki Shuji（Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University, Japan）, Takeda Yohei（Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University, Japan）, Hayashi Akihiro（Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University, Japan）, Matsumoto Kazuya（Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University, Japan）, Kawaguchi Koichiro（Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University, Japan）, Harada Kenichi（Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University, Japan）, Murawaki Yoshikazu（Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University, Japan） |
| 抄録 |
AIM：Helicobacter pylori（H. pylori）induces aberrant activation-induced cytidine deaminase（AID）expression in gastric epithelial tissues, which results in the accumulation of nucleotide alterations in the P53 gene. However, the relationship between AID and P53 expression is not fully understood, particularly in early gastric tumors. METHODS：This study analyzes immunohistochemical expression of AID and P53 in 129 early gastric carcinoma（EGC）samples obtained by endoscopic or surgical resection. Ninety-two cancer samples corresponded to intramucosal carcinoma, and 37 samples were submucosal invasive carcinomas. All patients were classified as having H. pylori infections by endoscopic atrophic changes or by testing seropositive for H. pylori）IgG. RESULTS：The rates of aberrant AID expression and P53 overexpression were 35.9% and 32.6% in intramucosal carcinomas, and 56.8% and 62.2% in submucosal invasive carcinomas, showing progressive increases during tumor progression（P＜0.01）. Aberrant AID expression was significantly associated with P53 overexpression in submucosal invasive carcinomas（P＜0.01）, but not in intramucosal carcinomas. Moreover, AID expression was associated with the severity of mononuclear cell activity in the non-cancerous mucosa adjacent to the tumor（P＜0.05）. CONCLUSION：These results indicate that aberrant AID expression by H. pylori infection could contribute to the induction of nuclear P53 expression in the early stage of gastric carcinogenesis. |
