| 共同演者 |
Takeda Hiroaki（Department of Gastroenterology, Yamagata Prefectural Central Hospital, Japan）, Sato Takeshi（Department of Gastroenterology, Faculty of Medicine, Yamagata University, Japan）, Abe Yasuhiko（Department of Gastroenterology, Faculty of Medicine, Yamagata University, Japan）, Nagino Ko（Department of Gastroenterology, Faculty of Medicine, Yamagata University, Japan）, Iwano Daisuke（Department of Gastroenterology, Faculty of Medicine, Yamagata University, Japan）, Yaoita Takao（Department of Gastroenterology, Faculty of Medicine, Yamagata University, Japan）, Yoshizawa Kazuya（Department of Gastroenterology, Faculty of Medicine, Yamagata University, Japan）, Yagi Makoto（Department of Gastroenterology, Faculty of Medicine, Yamagata University, Japan）, Mizumoto Naoko（Department of Gastroenterology, Faculty of Medicine, Yamagata University, Japan）, Kanno Nana（Department of Gastroenterology, Faculty of Medicine, Yamagata University, Japan）, Nishise Shoichi（Department of Gastroenterology, Faculty of Medicine, Yamagata University, Japan）, Kawata Sumio（Hyogo Prefectural Nishinomiya Hospital, Japan）, Ueno Yoshiyuki（Department of Gastroenterology, Faculty of Medicine, Yamagata University, Japan） |
| 抄録 |
Objective：It is acknowledged that chronic low-grade inflammation plays a key role in the development of obesity-related insulin resistance. The level of circulating IL-6, one of the major proinflammatory adipokines, is correlated with obesity and insulin resistance, which are thought to be risk factors for colorectal adenoma. We investigated the relationship between the IL-6 levels and the presence of adenoma in the context of insulin resistance. Method：In a total colonoscopy-based cross-sectional study, fasting serum levels of IL-6 were measured in blood obtained from 336 male participants（118 adenoma and 218 age-matched controls）. Results：In the adenoma group, the median levels of IL-6（1.24 vs. 1.04 pg/mL；p＜0.01）, insulin, and HOMA-IR were to be significantly higher than those in the control. Multiple logistic analyses adjusted to include HOMA-IR or insulin showed that the highest IL-6 quartile were associated with the presence of adenoma（OR 2.03；1.04-4.08, OR 2.06；1.02-4.15, respectively）. No significant interaction of IL-6 with HOMA-IR was observed. Conclusion：This study has indicated that increased levels of IL-6 are positively associated with the presence of adenoma in men, independently of insulin and HOMA-IR. Our findings suggest that IL-6 may be involved in the development of adenoma via a pathway different from that associated with insulin resistance and that low-grade systemic inflammation may play an active role in the etiology of colorectal adenoma. |
