| セッション情報 |
The 2nd JSGE International Topic Conference Poster Session
Cytokine
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| タイトル |
IT-P-19：Association of Serum IL6 Levels and Treatment Outcomes of PEG-IFN/RBV Combination Therapy or Hepatocarcinogenesis
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| 演者 |
Watanabe Takako（Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Japan） |
| 共同演者 |
Nakagawa Mina（Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Japan）, Kondo Mayumi（Toshima Hospital, Japan）, Sakamoto Naoya（Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Japan）, Asahina Yasuhiro（Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Japan）, Watanabe Mamoru（Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Japan） |
| 抄録 |
Background and Aims：IL6 is elevated in various types of chronic liver disease. In this study, we investigated the association of serum IL6 levels with outcomes of PEG-IFN/RBV combination therapy or carcniogenesis. Methods：We included 149 chronic hepatitis C（CHC）patients and measured serum IL6 levels at baseline and at 4, 8, and 12 weeks, and at the end of treatment in 49 patients. We performed univariate and multivariate regression analyses for the association of IL6 levels and various parameters and treatment responses. We also investigated the relationship between IL6 and carcinogenesis in 337 chronic hepatitis patients included CHC. Results：Pretreatment IL6 levels in male patients were inversely correlated with SVR in univariate analysis（p=0.012）. In male patients with SVR, serum IL6 levels decreased significantly at 4 weeks of treatment（p=0.029）and remained significantly lower than those of non-SVR patients in 4, 8 and 12 weeks of therapy. IL6 levels were significantly higher in the HCC patients compared to those in the non HCC among not only the LC but also the non LC group（p=0.039）. Nine parameters including IL6 were extracted in the univariate analysis as factors participating in HCC. Although IL6 was not extracted in a multivariate analysis, factors extracted such as gender, fibrosis and diabetes mellitus were suspected to be associated with IL6. Conclusion：Our results suggest that IL6 is correlated with not only treatment resistance but also carcinogenesis. |
| 索引用語 |
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