セッション情報 The 2nd JSGE International Topic Conference Poster Session

Virus, CRP and Anaphylatoxin

タイトル IT-P-28:

Post-operative Peak Serum C-reactive Protein Predicts Outcome of Hepatic Resection for Hepatocellular Carcinoma

演者 Fujiwara Yuki(Department of Surgery, The Jikei University School of Medicine, Japan)
共同演者 Shiba Hiroaki(Department of Surgery, The Jikei University School of Medicine, Japan), Futagawa Yauro(Department of Surgery, The Jikei University School of Medicine, Japan), Shimada Junichi(Department of Surgery, The Jikei University School of Medicine, Japan), Okui Norimitsu(Department of Surgery, The Jikei University School of Medicine, Japan), Kitamura Hiroaki(Department of Surgery, The Jikei University School of Medicine, Japan), Tsutsui Nobuhiro(Department of Surgery, The Jikei University School of Medicine, Japan), Wakiyama Shigeki(Department of Surgery, The Jikei University School of Medicine, Japan), Ishida Yuichi(Department of Surgery, The Jikei University School of Medicine, Japan), Misawa Takeyuki(Department of Surgery, The Jikei University School of Medicine, Japan), Yanaga Katsuhiko(Department of Surgery, The Jikei University School of Medicine, Japan)
抄録 Background:In spite of improvements in surgical managements, hepatocellular carcinoma(HCC)recurs postoperatively in as much as 60-70% of patients. Therefore, prediction of the tumor recurrence and prognosis is important for decision making in adjuvant treatment after surgery. We investigated the relation between post-operative serum C-reactive protein(CRP)and tumor recurrence as well as survival in patients with HCC after elective hepatic resection. Methods:The subjects were 77 patients who underwent elective hepatic resection for HCC between January 2001 and December 2008. We retrospectively examined the relation between post-operative serum CRP, clinical variables, and recurrence of HCC as well as overall survival. Results:In disease-free survival, pre-operative ICGR15 more than 15%(p=0.0039, p=0.0026), and advance tumor stage(p=0.0380, p=0.0203)were significant and independent predictors of poor survival rate in univariate and multivariate analyses. In overall survival, female gender(p=0.0052, p=0.0021), pre-operative ICGR15 above 15%(p=0.0043, p=0.0153), advance tumor stage(p=0.0063, p=0.0023), and post-operative peak serum CRP above 10 mg/dl(p=0.0309, p=0.0116)were significant and independent predictors of poor survival rate in univariate and multivariate analyses. Conclusion:Elevated post-operative serum CRP may be a prognostic indicator after elective hepatic resection for patients with HCC.
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