| 共同演者 |
Mizuno Suguru（Department of Gastroenterology, The University of Tokyo, Japan）, Isayama Hiroyuki（Department of Gastroenterology, The University of Tokyo, Japan）, Kogure Hirofumi（Department of Gastroenterology, The University of Tokyo, Japan）, Sasaki Takashi（Department of Gastroenterology, The University of Tokyo, Japan）, Nakai Yousuke（Department of Gastroenterology, The University of Tokyo, Japan）, Yamamoto Natsuyo（Department of Gastroenterology, The University of Tokyo, Japan）, Hirano Kenji（Department of Gastroenterology, The University of Tokyo, Japan）, Tada Minoru（Department of Gastroenterology, The University of Tokyo, Japan）, Yoshida Haruhiko（Department of Gastroenterology, The University of Tokyo, Japan）, Koike Kazuhiko（Department of Gastroenterology, The University of Tokyo, Japan） |
| 抄録 |
Background：Although CP has been considered high risk for PC, early diagnosis of PC is difficult. Methods：A）309 patients with CP between Jan 2002 and Dec 2011 were enrolled. The patients were checked by CT scan every year. Standardized incidence ratio（SIR）was estimated according to the age-stratified and sex-specific data. Characteristics of those developing PC were analyzed. B）537 patients with PC during the 10 years were enrolled. Each CT scan at the diagnosis of PC was reviewed and those with pancreatic calc on the CT were considered as having CP. Clinical stage of PC and overall survival were compared between those receiving regular follow-up for CP and symptomatic patients. Results：A）10 patients（3.2%）developed PC from CP during a median follow-up of 5.2 years, yielding an SIR of 15.2. All of the cancers were seen in calcified CP. Smoking and diabetes were other risk factors. B）16 patients（3.0%）had pancreatic calc, 7 of them were diagnosed as PC during the regular follow-up for CP. Clinical stage of PC in these 7 patients were 43%, 43%, and 14% in stage I-III, IVa, and IVb, which were earlier than symptomatic patients（14%, 25%, and 60%）. However, median survival of these two groups（14.7 vs 11.3 months）were not significantly different. Conclusion：Calcified CP, diabetes, and habitant of smoking had an increased risk of PC. Although regular follow-up for CP enabled the earlier diagnosis of PC, the prognosis was not different from symptomatic PC patients. |
