| セッション情報 |
International Session2(肝臓学会・消化器病学会合同)
Gene therapy and cell therapy through the liver; current aspects and future prospects
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| タイトル |
肝IS2-7指：Image-guided, Hydrodynamic Gene and Cell Delivery through the Liver: Toward Clinical Applications
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| 演者 |
K. Kamimura（Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University） |
| 共同演者 |
T. Suda（Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University）, Y. Aoyagi（Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University） |
| 抄録 |
The efficient and safe in vivo gene delivery to the hepatocytes is one of great milestones for gene and cell therapy treating various genetic and acquired disorders. For this purpose, we have focused on the hydrodynamic delivery that has been established as a simple, efficient, and reproducible method for delivery of DNA, siRNA, proteins, small compounds, viral vectors, and even cells in rodents. Efforts have been made to develop a clinically applicable procedure for hydrodynamic delivery to the liver in the past 10 years, which demonstrated the feasibility of applying the procedure to humans. This talk will focus on our recent work toward establishing an image-guided, computer-controlled hydrodynamic gene and cell delivery in various species including baboons. The successful application of hydrodynamic delivery in clinic will promise the safe and effective gene and cell therapy through the liver. |
| 索引用語 |
Hydrodynamic gene delivery, Gene therapy |
