| セッション情報 |
International Session8(消化器内視鏡学会・消化器病学会合同)
Recent advances in Interventional EUS 《Video》
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| タイトル |
内IS8-10：Endoscopic ultrasound-guided direct celiac ganglia versus celiac plexus neurolysis: A randomized multicenter trial
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| 演者 |
S. Doi（Japan EUS-CPN/CGN Study Group） |
| 共同演者 |
I. Yasuda（Japan EUS-CPN/CGN Study Group）, H. Kawakami（Japan EUS-CPN/CGN Study Group） |
| 抄録 |
Background and aim: In this multicenter randomized controlled trial, we compared the effectiveness of EUS-CGN and EUS-CPN in providing pain relief. Methods: Patients with upper abdominal cancer pain were randomly assigned to treatment using either EUS-CGN or EUS-CPN. Evaluation was performed at 7 days postoperatively using a pain scale of 0 to 10. Patients for whom pain decreased to less than 3 were considered to have a positive response, and those experiencing a decrease in pain to 0 or 1 were considered completely responsive. Comparison between the 2 groups was performed using intention-to-treat analysis. The primary endpoint was the difference in treatment response rates between EUS-CPN and EUS-CGN at postoperative day 7. Results: Thirty-four patients were assigned to each group. Visualization of ganglia was possible in 30 cases (88%) in the EUS-CGN group. On postoperative CT evaluation, ethanol distribution was significantly skewed in the EUS-CGN group. The positive response rate was significantly higher in the EUS-CGN group (73.5%) than in the EUS-CPN group (45.5%; p = 0.026). The complete response rate was also significantly higher in the EUS-CGN group (50.0%) than in the EUS-CPN group (18.2%; p = 0.010). There was no difference in adverse events or duration of pain relief between the 2 groups. Conclusion: EUS-CGN is significantly superior to conventional EUS-CPN in terms of providing effective pain relief to patients with upper abdominal cancer pain. |
| 索引用語 |
EUS-CGN, EUS-CPN |
