日本消化器病学会 アーカイブシステム

セッション情報 一般演題
タイトル O-35：

Involvement of DNA methylation alterations in SDH-deficient gastrointestinal stromal tumours
演者 三上　貴浩（東京大学大学院　医学系研究科　代謝生理化学教室　日本学術振興会特別研究員DC）
共同演者 弘田　幸子（東京大学大学院　医学系研究科　生物医化学教室）, 稲岡　ダニエル健（東京大学大学院　医学系研究科　生物医化学教室）, 坂井　千香（国立精神・神経医療研究センター 神経研）, 北　潔（東京大学大学院　医学系研究科　生物医化学教室）
抄録 Mutations of each subunit of mitochondrial complex II lead to tumourigenesis. The mechanism of this process is not clear, yet understanding of it is of importance for innovative therapies for SDH-deficient tumours. Recent studies suggest that SDH-deficient gastrointestinal stromal tumours (GISTs) accumulate succinate, leading to genome-wide DNA methylation alterations which then inhibit differentiation of the cells. Here, we have investigated whether DNA methylation is involved in cellular proliferation triggered by succinate accumulation. In DLD-1 cells, growth stimulatory effect induced by succinate under hypoxic condition was reversed by decitabine, a hypomethylating agent, suggesting the possibility that succinate promotes cellular growth through DNA methylation.
索引用語 GIST, SDH