| セッション情報 |
The 4th International Forum
II Challenge to the pancreatic and biliary cancers 2. Pancreatic cancer―Challenge to the early detection
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| タイトル |
IFII-2-2：Pancreatic ductal adenocarcinoma derived from IPMN and pancreatic ductal adenocarcinoma concomitant with IPMN
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| 演者 |
Yamaguchi, Team 3 of Committee for cystic tumors of the pancreas, Japan Pancreas Society Koji（Department of Surgery 1, University of Occupational and Environmental Health, Japan） |
| 共同演者 |
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| 抄録 |
Background：Pancreatic ductal adenocarcinoma（PDAC）of the pancreas may derive from intraductal papillary mucinous neoplasm（IPMN）of the pancreas and PDAC may develop in the pancreatic duct apart from IPMN. Whether these two entities have different biological features from ordinary PDAC remains unknown.
Purposes：Clinicpathologic features of these two entities were compared with those of ordinary PDAC.
Subjects：A total of 765 patients with IPMN surgically resected were divided into six groups；381 with adenoma, 157 with non-invasive carcinoma, 44 with minimally invasive carcinoma, 122 with PDAC derived from IPMN, 31 with PDAC concomitant with IPMN and 30 with PDAC undetermined if derived from IPMN or concomitant with IPMN.
Results：The mean ages of the two groups of PDAC were higher than that of ordinary PDAC. Mucinous carcinoma was more frequently present in PDAC derived from IPMN than in PDAC concomitant with IPMN and ordinary PDAC. PDACs derived from IPMN and concomitant with IPMN were significantly smaller in size, less invasive, and less extensive than ordinary PDAC. The median survivals of the two conditions were significantly longer than that of ordinary PDAC when compared overall or when limited to TS2（2.0cm＜tumor size≦4.0cm）or TS3（4.0cm＜tumor size≦6.0cm）cases.
Conclusions：These findings suggest that PDAC concomitant with IPMN and PDAC derived from IPMN may have more favorable biological behaviors or be diagnosed earlier than ordinary PDAC. |
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