| セッション情報 | The 4th International ForumShort Oral Presentations（GI mucosal injury 1） |
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| タイトル | IF-SOP-3：The comparison of selective cyclooxygenase-2 inhibitor induced small bowel injury with loxoprofen：A randomized cross-over study in healthy subjects |
| 演者 | Mizukami Kazuhiro（Department of Gastroenterology, Oita University, Japan） |
| 共同演者 | Murakami Kazunari（Department of Gastroenterology, Oita University, Japan） |
| 抄録 | Aim：Nonsteroidal anti-inflammatory drugs is found to result in not only the upper gastrointestinal injury but also small bowel injury. Celecoxib（a selective cyclooxygenase-2 inhibitor）is said to be a drug with a little effect on the entire digestive tract mucosa. The present study was conducted to compare the extents of small bowel mucosal injury induced by celecoxib and loxoprofen（the most frequently used nonsteroidal anti-inflammatory drugs in Japan）. Methods：Ten healthy adult males were administered celecoxib（200 mg/day, Group C）and loxoprofen（180 mg/day, Group L）in a cross over design for 14 days, and the influence of each drug on small bowel mucosa was evaluated by comparing pre- and post-treatment capsule endoscopy findings. We measured the percentage of patients with small bowel mucosal injury following administration of these drugs as primary endpoint. Additionally, mean number of small bowel mucosal injuries per subject were analyzed as secondary endpoint. Results：The percentage of subjects appeared small bowel mucosal injury as primary endpoint was 10% in Group C and 70% in Group L after treatment. This magnitude of the difference of between Group C and Group L was statistically significant（P=0.031）. As for the number of small bowel mucosal injuries as secondary endpoint, the influence of celecoxib on small bowel injury significantly had less than that of loxoprofen. Conclusion：These results indicate that celecoxib has less influence on small bowel mucosa than loxoprofen and can be used safely. Keywords：capsule endoscopy, celecoxib, loxoprofen, nonsteroidal anti-inflammatory drug, small bowel injury |
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