日本消化器病学会 アーカイブシステム

セッション情報 The 4th International Forum

Short Oral Presentations（GI mucosal injury 2）
タイトル IF-SOP-6：

The protective role of genistein on gastric mucosal lesion induced by paracetamol
演者 Mustika　Syifa（Gastroenterohepatology Division, Internal Medicine Department, Faculty of Medicine, Brawijaya University, Indonesia）
共同演者 Prahudi　Andri（Gastroenterohepatology Division, Internal Medicine Department, Faculty of Medicine, Brawijaya University, Indonesia）, Ahmad　Harijono（Gastroenterohepatology Division, Internal Medicine Department, Faculty of Medicine, Brawijaya University, Indonesia）
抄録 Background：
Paracetamol, a widely used antipyretic and analgesic drug has been considered a safer alternative to NSAIDs. However, several studies showed that at high doses it increased the risk of upper gastrointestinal complications and liver toxicity. Oral genistein had antiulcerogenic activity by protecting gastric mucosal and as an antioxidant.
Objective：
The present study was aimed to investigate the effects of administering genistein and silymarin on gastric mucosal lesionin Wistar rats fed with toxic dose of paracetamol.
Methods：
An experimental study was conducted using 60 male rats were categorized into 3 groups. The first group was control group treated with 600 mg/kg BW of oral paracetamol. The other groups were treated with 600 mg/kg BW paracetamol and additional 2 mg/kg BW genistein, 50mg/kg BW silymarin. The measured parameter was gastric mucosal lesion range from erosion to ulcer seen macroscopically and degree of inflammation such as leukocytes and lymphocytes were observed by histopathological examination. Data were analyzed statistically by ANOVA.
Results：
Genistein group showed lower degree of gastric ulcer and erosion significantly compare to other groups（p=0.004 and p=0.001）. Silymarin less protective than genistein and even shows higher degree of ulcer compared to control group（p=0.457）. Genistein group also had the least degree of inflammation（p=0,001）.
Conclusion：
Genistein supplementation attenuated gastric mucosal lesion, likely due to its ability in decreasing inflammation process and antioxidant effect.

Keywords：
Genistein, paracetamol, gastric mucosal lesion
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