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New Insights into the Molecular Pathogenesis of Intrahepatic Cholangiocarcinoma
Patel Tushar(Department of Transplantation, Mayo Clinic Florida, USA)
Intrahepatic cholangiocarcinoma(ICC)is an aggressive malignancy which has a very poor prognosis. The mechanisms involved in the pathogenesis of these cancers are not well understood. Recent epidemiolo...

第99回日本消化器病学会総会5)Inflammation and Carcinogenesis in the Biliary Tract and Pancreas

Characteristics of Biliary Tract Cancer in Patients with Pancreaticobiliary Maljunction:The Report of Japan-Nationwide Survey
Shimada Mitsuo(Japanese Study Group on Pancreaticobiliary Maljunction, Department of Surgery, The University of Tokushima, Japan)
Introduction:Pancreaticobiliary maljunction(PBMJ)is well known to be an important risk of biliary tract cancer. We herein report characteristics of biliary tract cancer in patients with PBMJ as...

第99回日本消化器病学会総会5)Inflammation and Carcinogenesis in the Biliary Tract and Pancreas

EGF Receptor Signaling is Essential for Initiation of Pancreatic Ductal Adenocarcinoma
Navas Carolina(Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas(CNIO), Spain, Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Austria)
EGFR and K-Ras mutations are mutually exclusive in NSCLC and in CRC, suggesting that they act in the same signaling pathway. However, ablation of EGFRs in pancreatic acinar cells completely prevents d...

第99回日本消化器病学会総会5)Inflammation and Carcinogenesis in the Biliary Tract and Pancreas

Identification of Inflammatory Signal-stimulating microRNA in Pancreatic Duct Cell Carcinoma
Hamada Shin(Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan)
Pancreatic duct cell carcinoma(PDAC)is a lethal disease due to the invasive growth and rapid dissemination. PDAC shows a characteristic histological feature, desmoplasia which results from continuous ...

第99回日本消化器病学会総会5)Inflammation and Carcinogenesis in the Biliary Tract and Pancreas