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Apoptosis Promotes Oncogenic Potential in DEN-administrated Mice
Tanaka Satoshi(Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Japan)
Background and Aim:Apoptosis serves as an important mechanism by removing DNA damaged-cells and is considered to inhibit carcinogenesis. On the other hand, hepatocyte apoptosis is a key feature...

第99回日本消化器病学会総会Oxidative Stress and Apptosis

Antioxidant Has a Therapeutic Potential for HCC Driven by Chronic Liver Injury
Hikita Hayato(Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Japan)
Background and Aim:Continuous hepatocyte apoptosis is a hallmark for chronic viral hepatitis or non-alcoholic steatohepatitis, which is a high-risk condition for HCC. Although we have reported ...

第99回日本消化器病学会総会Oxidative Stress and Apptosis

Changes of Cytokines in Cirrhosis Patients with Advanced Hepatocellular Carcinoma Treated by Sorafenib
Nagai Hidenari(Division of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, Toho University School of Medicine, Japan)
BACKGROUND:Tumor necrosis factor(TNF)is known to induce apoptosis of tumor cells by binding to TNF-related apoptosis-inducing ligand. Binding of the Fas ligand on cytotoxic T lymphocytes to the Fas re...

第99回日本消化器病学会総会Oxidative Stress and Apptosis

Suppressed Mitophagy in Transgenic Mice Expressing Hepatitis C Virus Polyprotein
Hara Yuichi(Hepatology and Pancreatology, Kawasaki Medical School, Japan)
We previously demonstrated that the presence of impaired mitochondria is critical for HCV-associated hepatocarcinogenesis in mice. Impaired mitochondria are selectively eliminated through autophagy-de...

第99回日本消化器病学会総会Oxidative Stress and Apptosis

Low-dose Interferon Improved Alpha-fetoprotein Levels and Iron Metabolic Disorder in Patients with Hepatitis C Virus Infection Bearing Non-interferon Sensitive IL28B Single Nucleotide Polymorphisms
Takeda Tsutomu(The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine(NCGM), Japan)
Background and Aim:Long-term, low-dose Peg-IFN administration has been shown to reduce the incidence of hepatocellular carcinoma in patients with liver cirrhosis infected with HCV. The aim of the stud...

第99回日本消化器病学会総会Oxidative Stress and Apptosis