- Current and Future Anti-fibrotic Therapies for Chronic Liver Disease
Rockey Don C.（Department of Internal Medicine, Medical University of South Carolina, USA）
Understanding the basic mechanisms underlying chronic liver disease will lead to novel therapies for this disease. Indeed, lessons from cell biology can be applied to cirrhosis and moreover, cirrhosis...
- The Role of Hepatic Stellate Cells in Fibrogenesis
Kawada Norifumi（Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan）
Molecular analysis of hepatic fibrogenesis has progressed with respect to both fibrosis progression and regression by using cell biological, molecular biological, and（epi）genetic approaches. Recent re...
- Contribution of Hepatic Stellate Cells and Liver Fibrosis to Hepatocarcinogenesis
Schwabe Robert F.（Department of Medicine, Columbia University, USA）
Although 80% of hepatocellular carcinomas（HCCs）arise in fibrotic livers, it remains elusive whether hepatic fibrosis promotes HCC. The link between fibrosis and HCC has been difficult to establish as ...
- Development of New Cell Therapy for Liver Fibrosis
Terai Shuji（Department of Gastroenterology ＆ Hepatology, Yamaguchi University Graduate School of Medicine, Japan）
Liver cirrhosis patients generally progress to liver failure. To cure this progressive disease, we developed a novel cell therapy using bone marrow cells；autologous bone marrow cell infusion（ABMi<...
- Treatment of Liver Fibrosis Using siRNA against a Collagen-specific Chaperone, Encapsulated in Vitamin A Coupled Liposomes
Niitsu Yoshiro（Department of Molecular Target Exploration School of Medicine Sapporo Medical University, Japan）
Despite the recent introduction of various antiviral agents, treatment of cirrhosis due to viral hepatitis is still an unmet medical need. Further, cirrhosis resulted from non-alcoholic steatohepatiti...