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Wnt/β-Catenin Signaling during Intestinal Tumorigenesis Requires Cdc42 Activity
Sakamori Ryotaro(Department of Gastroenterology and Hepatology, Osaka University School of Medicine, Japan)
Genetic tracing experiments in mice have revealed that intestinal stem cells harboring gain-of-function mutations in Wnt/β-Catenin signaling components expand rapidly into the resultant colorectal can...

第99回日本消化器病学会総会Caricinogenesis of Colon Cancer

Stabilization of Atoh1 Protein by TNF-α in Colon Cancer Acquires Cancer Stemness
Fukushima Keita(Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Japan)
The patients with ulcerative colitis are at increased risk of developing colitic cancer. Colitic cancer has been reported to acquire the chemoresistance, resulting in the poorer prognosis than that of...

第99回日本消化器病学会総会Caricinogenesis of Colon Cancer

Circulating Levels of IL-6, Insulin Resistance and Risk of Colorectal Adenoma in Men
Sasaki Yu(Department of Gastroenterology, Faculty of Medicine, Yamagata University, Japan)
Objective:It is acknowledged that chronic low-grade inflammation plays a key role in the development of obesity-related insulin resistance. The level of circulating IL-6, one of the major proinflammat...

第99回日本消化器病学会総会Caricinogenesis of Colon Cancer