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The Regulation of Lymphotoxin-β is Involved in the Higher-order Chromatin Conformation of the TNF/LT Locus in Hepatocellular Carcinoma Cells
Watanabe Takehisa(Department of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto University, Japan)
The tumor necrosis factor(TNF)superfamily members, TNF(initially termed TNF-α), lymphotoxin-α(LTα), and lymphotoxin-β(LTβ), are major pro-inflammatory cytokines that mediate inflammatory responses. In...

第99回日本消化器病学会総会Cytokine

Association of Serum IL6 Levels and Treatment Outcomes of PEG-IFN/RBV Combination Therapy or Hepatocarcinogenesis
Watanabe Takako(Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Japan)
Background and Aims:IL6 is elevated in various types of chronic liver disease. In this study, we investigated the association of serum IL6 levels with outcomes of PEG-IFN/RBV combination therapy or ca...

第99回日本消化器病学会総会Cytokine

Macrophage Colony-stimulating Factor Plays a Pivotal Role in Hepatocarcinogenesis in Human and Mice
Kono Hiroshi(First Department of Surgery, University of Yamanashi, Japan)
Aim;The purpose of this study was to investigate the role of macrophage colony-stimulating factor(M-CSF)in hepatocarcinogenesis. Materials and Method;In animal studies, op/op and their littermate mic...

第99回日本消化器病学会総会Cytokine

Progressive Depletion of Hepatic NKT Cells in Steatohepatitis with Tumorigenesis Caused by Hepatocyte-specific Pten Deficiency
Miyaji Takashi(Department of Gastroenterology, Juntendo University Graduate School of Medicine, Japan)
Background:The innate immune system plays a pivotal role in the pathogenesis of NASH;however, the role of hepatic NKT cells in tumorigenesis based on steatohepatitis has not been well elucidate...

第99回日本消化器病学会総会Cytokine